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American Journal of Alzheimer's Disease and Other Dementias®
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Neural Stem Cells and Alzheimer's Disease: Challenges and Hope

Zhongling Feng, MD, PhD

Bio Group, Nitto Denko Technical Corporation, Oceanside, California, Zhongling_feng{at}gg.nitto.co.jp

Gang Zhao, PhD

Bio Group, Nitto Denko Technical Corporation, Oceanside, California

Lei Yu, MD, PhD

Bio Group, Nitto Denko Technical Corporation, Oceanside, California

Alzheimer's disease is characterized by degeneration and dysfunction of synapses and neurons in brain regions critical for learning and memory functions. The endogenous generation of new neurons in certain regions of the mature brain, derived from primitive cells termed neural stem cells, has raised hope that neural stem cells may be recruited for structural brain repair. Stem cell therapy has been suggested as a possible strategy for replacing damaged circuitry and restoring learning and memory abilities in patients with Alzheimer's disease. In this review, we outline the promising investigations that are raising hope, and understanding the challenges behind translating underlying stem cell biology into novel clinical therapeutic potential in Alzheimer's disease.

Key Words: neural stem cells • Alzheimer's disease • neurogenesis • therapy

This version was published on February 1, 2009

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 24, No. 1, 52-57 (2009)
DOI: 10.1177/1533317508327587
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