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American Journal of Alzheimer's Disease and Other Dementias®
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Integrated treatment approach improves cognitive function in demented and clinically depressed patients

Valentin Bragin, MD, PhD

Marina Chemodanova, PhD

Narmina Dzhafarova, MD

Ilya Bragin, BA

Jennifer L. Czerniawski, BA

Stress Relief and Memory Training Center, Brooklyn, New York

Gjumrakch Aliev, MD, PhD

Microscopy Research Center, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio

The purpose of this study was to evaluate the efficacy of an integrative treatment approach on cognitive performance. The study sample comprised 35 medically ill patients (20 male, 15 female) with an average age of 71.05, who were diagnosed with mild dementia and depression. These patients were evaluated at baseline and at six, 12, and 24 months of treatment, which included antidepressants (sertraline, citalopram, or venlafaxine XR, alone or in combination with bupropion XR), cholinesterase inhibitors (donepezil, rivastigmine or galantamine), as well as vitamins and supplements (multivitamins, vitamin E, alpha-lipoic acid, omega-3 and coenzyme Q-10). Patients were encouraged to modify their diet and lifestyle and perform mild physical exercises. Results show that the integrative treatment not only protracted cognitive decline for 24 months but even improved cognition, especially memory and frontal lobe functions.

Key Words: dementia • depression • Alzheimer's disease • SSRI • cholinesterase inhibitors • integrative treatment • memory • frontal lobe

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 20, No. 1, 21-26 (2005)
DOI: 10.1177/153331750502000103
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