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American Journal of Alzheimer's Disease and Other Dementias®
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Article

Eye Tracking During a Visual Paired Comparison Task as a Predictor of Early Dementia

Michael D. Crutcher, PhD, Rose Calhoun-Haney, PhD, Cecelia M. Manzanares*, James J. Lah, MD, PhD, Allan I. Levey, MD, PhD, and Stuart M. Zola, PhD

* To whom correspondence should be addressed. E-mail: cmanzan{at}emory.edu.


   Abstract

The authors present findings from a behavioral task (visual paired comparison) using infrared eye-tracking that could potentially be useful in predicting the onset of Alzheimer’s disease. Delay intervals of 2 seconds and 2 minutes were used between the initial viewing of a picture and when the picture was displayed alongside a novel picture. Eye-tracking revealed that at the 2-second delay, 6 patients with mild cognitive impairment, 15 matched control participants (normal control), and 4 neurological control participants with Parkinson’s disease performed comparably, viewing the novel picture greater than 71% of the time. When the delay increased to 2 minutes, patients with mild cognitive impairment viewed the novel picture only 53% of the time (P < .05), while control participants and participants with Parkinson disease remained above 70%. These findings demonstrate the usefulness of this task for assessing normal as well as impaired memory function.

First published on February 26, 2009, doi:10.1177/1533317509332093

American Journal of Alzheimer's Disease and Other Dementias® 2009;24:258.

A more recent version of this article appeared on June 1, 2009


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