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American Journal of Alzheimer's Disease and Other Dementias®
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*Compound via MeSH
*Substance via MeSH
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*Female Sexual Dysfunction
*Lewy Body Disease
*Mental Health
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Article

Quetiapine Effective in Treatment of Inappropriate Sexual Behavior of Lewy Body Disease With Predominant Frontal Lobe Signs

Ravi Prakash, MBBS, DPM*, Amit Pathak, MBBS, DPM, Sanjay Munda, MBBS, DPM, MD, and Dhruv Bagati, MBBS, DPM

Central Institute of Psychiatry, Kanke, India

* To whom correspondence should be addressed. E-mail: drravi2121{at}gmail.com.


   Abstract

Dementia of Lewy body disease is the second most common degenerative cause of dementia after Alzheimer’s disease, among all the dementias. The core features are a progressive dementia, fluctuations in cognitive functions, visual hallucinations, and spontaneous parkinsonism. Rapid eye movement sleep behavior disorder, severe neuroleptic sensitivity, and low dopamine transporter uptake in basal ganglia are other suggestive features. Behavioral abnormalities are commonly present in the form of aggressive behavior, irritability, and disinhibited behaviors. These are mostly seen in the advanced stages of dementia. However, inappropriate sexual behavior is uncommonly seen in such cases. Three types of inappropriate sexual behaviors commonly found in cases of dementia are sex talks, sexual acts, and implied sexual acts. Such inappropriate sexual behaviors have not been described adequately in dementia of Lewy body disease. We report inappropriate sexual behaviors in a case of dementia of Lewy body disease, which improved rapidly after treatment with quetiapine.

First published on January 7, 2009, doi:10.1177/1533317508329479

American Journal of Alzheimer's Disease and Other Dementias® 2009;24:136.

A more recent version of this article appeared on April 1, 2009
This version was published on February 3, 2009


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