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American Journal of Alzheimer's Disease and Other Dementias®
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Article

Current Concepts in Alzheimer's Disease: A Multidisciplinary Review

Ludovico Minati, MSc*, Trudi Edginton, PhD, Maria Grazia Bruzzone, MD, and Giorgio Giaccone, MD

* To whom correspondence should be addressed. E-mail: lminati{at}istituto-besta.it.


  Abstract

This comprehensive, pedagogically-oriented review is aimed at a heterogeneous audience representative of the allied disciplines involved in research and patient care. After a foreword on epidemiology, genetics, and risk factors, the amyloid cascade model is introduced and the main neuropathological hallmarks are discussed. The progression of memory, language, visual processing, executive, attentional, and praxis deficits, and of behavioral symptoms is presented. After a summary on neuropsychological assessment, emerging biomarkers from cerebrospinal fluid assays, magnetic resonance imaging, nuclear medicine, and electrophysiology are discussed. Existing treatments are briefly reviewed, followed by an introduction to emerging disease-modifying therapies such as secretase modulators, inhibitors of Abeta aggregation, immunotherapy, inhibitors of tau protein phosphorylation, and delivery of nerve growth factor.

First published on December 30, 2008, doi:10.1177/1533317508328602

American Journal of Alzheimer's Disease and Other Dementias® 2009;24:95.

A more recent version of this article appeared on April 1, 2009

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