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The Japanese MCI Screen for Early Detection of Alzheimer's Disease and Related Disorders

^* To whom correspondence should be addressed. E-mail: tyamada{at}fukuoka-u.ac.jp.

	Abstract

Early detection of Alzheimer’s disease and related disorders in Japan is increasingly important. The Mild Cognitive Impairment Screen (MCIS)—derived from the National Institute of Aging CERAD neuropsychologic battery—differentiates normal aging from MCI and mild dementia with 97.3% and 99% accuracy, respectively. The Japanese MCIS (JMCIS), Mini-Mental State Examination (MMSE), quantitative SPECT (qSP), and quantitative MRI (qMRI) were used to classify 63 outpatients at Fukuoka University Hospital who were either normal or had MCI based on Clinical Dementia Rating scores of 0 and 0.5, respectively. Performance statistics for the JMCIS, MMSE, qSP, and qMRI were, respectively: (1) accuracy = 0.964, 0.768, 0.722, 0.733; (2) sensitivity = 0.958, 0.792, 0.688, 0.700; (3) specificity = 1.000, 0.625, 1.000, 1.000; and (4) validity = 0.813, 0.420, 0.296, 0.308. This initial study shows negligible differences between the English and Japanese MCIS, supporting its potential use for early detection in Japan.

First published on January 25, 2008, doi:10.1177/1533317507312624

American Journal of Alzheimer's Disease and Other Dementias® 2008;23:162.

A more recent version of this article appeared on May 1, 2008


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