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American Journal of Alzheimer's Disease and Other Dementias®
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*Alzheimer's Disease
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Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review

Ludovico Minati, MSc

Science Direction, unit, Fondazione IRCCS Istituto Nazionale Neurologico "Carlo Besta", Milano, Italy, Neuroradiology, unit, Fondazione IRCCS Istituto Nazionale Neurologico "Carlo Besta", Milano, Italy, lminati{at}istituto-besta.it

Trudi Edginton, PhD

Cognitive Science Research Unit University of Westminster, London, United Kingdom

Maria Grazia Bruzzone, MD

Neuroradiology, unit, Fondazione IRCCS Istituto Nazionale Neurologico "Carlo Besta", Milano, Italy

Giorgio Giaccone, MD

Neuropathology, unit, Fondazione IRCCS Istituto Nazionale Neurologico "Carlo Besta", Milano, Italy

This comprehensive, pedagogically-oriented review is aimed at a heterogeneous audience representative of the allied disciplines involved in research and patient care. After a foreword on epidemiology, genetics, and risk factors, the amyloid cascade model is introduced and the main neuropathological hallmarks are discussed. The progression of memory, language, visual processing, executive, attentional, and praxis deficits, and of behavioral symptoms is presented. After a summary on neuropsychological assessment, emerging biomarkers from cerebrospinal fluid assays, magnetic resonance imaging, nuclear medicine, and electrophysiology are discussed. Existing treatments are briefly reviewed, followed by an introduction to emerging disease-modifying therapies such as secretase modulators, inhibitors of Abeta aggregation, immunotherapy, inhibitors of tau protein phosphorylation, and delivery of nerve growth factor.

Key Words: Alzheimer's disease • neuropathology • neuropsychological testing • neuroimaging • pharmacotherapy

References

This version was published on April 1, 2009

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 24, No. 2, 95-121 (2009)
DOI: 10.1177/1533317508328602
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This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Minati, L.
Right arrow Articles by Giaccone, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Minati, L.
Right arrow Articles by Giaccone, G.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*Alzheimer's Disease
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

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