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Computerized Cognitive Assessment of Mild Cognitive Impairment in Urban African Americans

Department of Clinical Science, NeuroTrax Corporation, Newark, New Jersey, glen.doniger{at}neurotrax.com

Mi-Yeoung Jo, PsyD

Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York

Ely S. Simon, MD

Department of Clinical Science, NeuroTrax Corporation, Newark, New Jersey, Department of Neurology, Albert Einstein College of Medicine, Bronx, New York

Howard A. Crystal, MD

Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York

Few objective cognitive assessment tools have been validated for mild cognitive impairment (MCI) in African Americans despite higher prevalence of disease. This preliminary study evaluated discriminant validity of a computerized cognitive assessment battery for MCI in an urban African American cohort. Twenty-seven participants with MCI and 22 cognitively healthy individuals completed a multidomain battery (Mindstreams, NeuroTrax Corp, New Jersey). Mild cognitive impairment participants performed more poorly than cognitively healthy participants in all domains, with significant differences in memory (P = .003; d = 0.96), executive function (P = .046; d = 0.64), and overall battery performance (P = .041; d = 0.63). Adjustment for intelligence quotient (IQ) yielded significant differences in memory (P < .001; d = 1.34), executive function (P = .007; d = 0.86), attention (P = .014; d = .80), and overall performance (P = .001; d = 1.09). Such a validated battery may help to address an important clinical need in this population.

Key Words: cognitive assessment • mild cognitive impairment • MCI • African American • computerized battery

This version was published on October 1, 2009

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 24, No. 5, 396-403 (2009)
DOI: 10.1177/1533317509342982


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