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ApoE Genotype and Family History in Patients With Dementia and Cognitively Intact Spousal Controls

Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg School of Medicine, Regensburg, Germany, maria.zintl{at}web.de

Gerd Schmitz, MD, PhD

Department of Institut for Clinical Chemistry and Laboratory Medicine, University of Regensburg School of Medicine, Regensburg, Germany

Göran Hajak, MD, PhD

Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg School of Medicine, Regensburg, Germany

Hans-Hermann Klünemann, MD, PhD

Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg School of Medicine, Regensburg, Germany

Objective: To test that a positive family history and ApoE e4 genotype are prevalent among dementia patients with onset before 70 years of age compared with healthy spousal controls. Methods: A total of 210 patients with dementia and 82 spousal control participants. Neuropsychiatric examination, Consortium to establish a registry on Alzheimer’s disease test battery, Clock-drawing Test, and ApoE genotyping were performed in patients and controls. Results: Of the 131 patients with Alzheimer dementia, 25 were homozygous for Apo e4. Among dementia patients with a positive family history (n = 83), homozygosity for the Apo e4 genotype was found in 19 (22.9%). A positive family history was highest among Apo e4 homozygous Alzheimer dementia patients (72.0%) and lowest among the cognitively normal spousal controls (9.3%). Conclusions: In our sample of patients with Alzheimer dementia, approximately 3 of 4 (72.0%) were homozygous for the genotype Apo e4 when they had a positive family history.

Key Words: dementia • Alzheimer’s disease • ApoE • family history

This version was published on August 1, 2009

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 24, No. 4, 349-352 (2009)
DOI: 10.1177/1533317509333040


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