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Association Between Progranulin and β-Amyloid in Dementia With Lewy Bodies

Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania

Andrea Rosso, MPH

Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania

Carol F. Lippa, MD

Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania, Clippa{at}DrexelMed.edu

Recent studies demonstrated that progranulin plays an integral role in the pathogenesis of frontotemporal dementia. To begin to explore the role of progranulin in dementia with Lewy bodies, we investigate its association with pathologic proteins that characterize this disease. We assessed immunoreactivity for progranulin in medial temporal lobe structures of 12 cases of dementia with Lewy bodies. Similar data were collected for β-amyloid burden, and -synuclein pathology. Blinded investigators used a 0-3—point scale to quantify progranulin burden. Double labeling for progranulin and β-amyloid was also performed. We were able to demonstrate progranulin immunoreactivity throughout the medial temporal lobe in all dementia with Lewy body cases. We identified a significant positive correlation (r = 0.606; P = .037) between β-amyloid burden and progranulin. There was no significant correlation between -synuclein pathology or Braak stage and progranulin. Progranulin and β-amyloid co-localized in plaques in dementia with Lewy bodies, suggesting that there is likely a biological association between these 2 aggregated proteins.

Key Words: progranulin • β-amyloid • dementia with Lewy bodies • synucleinopathies • frontotemporal dementia

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 23, No. 5, 488-493 (2008)
DOI: 10.1177/1533317508321910


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