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American Journal of Alzheimer's Disease and Other Dementias®
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Review: Caffeine: Neuroprotective Functions in Cognition and Alzheimer's Disease

Andi Rosso, MPH

Department of Neurology Drexel University College of Medicine, alr44{at}drexel.edu, Department of Epidemiology and Biostatistics Drexel University School of Public Health, Philadelphia, Pennsylvania

Jana Mossey, PhD

Department of Epidemiology and Biostatistics Drexel University School of Public Health, Philadelphia, Pennsylvania

Carol F. Lippa, MD

Department of Neurology Drexel University College of Medicine

Alzheimer's disease is a common problem in our elderly population. Although research is leading to improvements in our understanding of the underlying biology, we still have little understanding of the environmental risk factors associated with this disorder. Caffeine, an easily modifiable environmental factor, may have a protective effect on the likelihood of developing Alzheimer's disease. This article reviews the association between caffeine from both a biologic and epidemiologic perspective. Further studies are needed to determine whether caffeine consumption could have a major affect on the development of Alzheimer's disease or age-related cognitive decline.

Key Words: caffeine • Alzheimer's disease • aging • cognition • adenosine receptors • epidemiology • risk factors

This version was published on October 1, 2008

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 23, No. 5, 417-422 (2008)
DOI: 10.1177/1533317508320083
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