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American Journal of Alzheimer's Disease and Other Dementias®, Vol. 23, No. 3, 286-290 (2008)
DOI: 10.1177/1533317507313675

The Clinical Significance of Plasmatic Amyloid Aβ-40 Peptide Levels in Alzheimer's Disease Patients Treated With Galantamine

Pedro J. Modrego, MD

Neurology Department, Miguel Servet University Hospital, pmodrego{at}salud.aragon.es

Inmaculada Monleon, ChD

Araclon Biotech University of Zaragoza

Manuel Sarasa, PhD

Laboratory of Neurobiology, University of Zaragoza, Zaragoza, Spain

To date there are no conclusive reports on the usefulness of determining amyloid peptides in the serum of patients with Alzheimer's disease (AD). Only anecdotal works deal with the changes in the peptides produced by cholinesterase inhibitors. In this study, the authors investigated and studied the clinical significance of plasmatic Aβ-40 and Aβ-42 peptide levels in a series of 34 consecutive patients with AD. The baseline levels of the Aβ-40 peptide correlated negatively with the Mini Examen Cognoscitivo (Spanish version of the Mini-Mental test) score. Complete follow-up was possible in 22 patients. After 6 months of treatment with galantamine, the mean Aβ-40 peptide levels decreased from 31.86 to 24.22 pg/mL. The baseline levels of Aβ-40 were predictive of response to treatment in the Alzheimer's Disease Assessment Scale—Cognitive Subscale. The authors conclude that determining plasmatic Aβ-40 peptide levels could be useful in predicting and monitoring response to treatment in AD.

Key Words: Alzheimer disease • plasmatic Aβ-40 peptide


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