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American Journal of Alzheimer's Disease and Other Dementias®, Vol. 22, No. 3, 223-228 (2007)
DOI: 10.1177/1533317507299415

The Role of Apolipoprotein E in Cognitive Decline and Delirium after Bypass Heart Operations

Georgios I. Tagarakis, MD

Herz- und Gefaess-Klinik, Rhoen Klinikum, Bad Neustadt a.d. Saale, Germany, gtagarakis@ hotmail.com

Fani Tsolaki-Tagaraki, MD

Herz- und Gefaess-Klinik, Rhoen Klinikum, Bad Neustadt a.d. Saale, Germany

Magdalini Tsolaki, MD, PhD

3rd Department of Neurology, Aristotle University of Thessaloniki, Greece

Anno Diegeler, MD, PhD

Herz- und Gefaess-Klinik, Rhoen Klinikum, Bad Neustadt a.d. Saale, Germany

Nikolaos B. Tsilimingas, MD, PhD

Cardiothoracic Department, University of Thessaly, Greece

Andreas Papassotiropoulos, MD, PhD

Department for Psychiatric Research, University of Zurich, Switzerland

Cognitive decline and delirium are common complications after heart bypass surgery. Based on the reported role of the APOE-{varepsilon}4 allele in neurodegenerative diseases, we studied its association with these complications. A neuropsychological test battery consisting of the Mini Mental State Examination, the Wechsler's Memory Scale Revised, the Brief Psychiatric Rating Scale, and the Delirium Rating Scale was applied to 137 APOE-genotyped patients on admission and 1 month after bypass surgery. We correlated the APOE (apolipoprotein E) polymorphism with the postoperative test outcome by taking into account all factors known to influence cognitive capacity after heart surgery. There was a significant decline in all test results 1 month after surgery and a high frequency of postoperative delirium. Neither this decline nor the frequency of delirium was associated with the APOE-{varepsilon}4 allele. This study confirms the high incidence of cognitive decline and delirium after coronary surgery, but it does not support the role of the APOE-{varepsilon}4 allele in the occurrence of these complications.

Key Words: CABG • neurocognitive deficits • dementia • genetics


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