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Sensory Gating in Patients With Alzheimer’s Disease and Their Biological Children

Edith Nourse Rogers Memorial Veteran’s Hospital, GRECC, Bedford, Massachusetts, Boston University School of Medicine, Department of Neurology, Cognitive Neuroscience Division of the Alzheimer’s Disease Center, bally{at}bu.edu

Gary E. Jones, PhD

Department of Psychology, Louisiana State University, Shreveport

Jack A. Cole, PhD

Danville VA Medical Center, Danville, Illinois

Andrew E. Budson, MD

Edith Nourse Rogers Memorial Veteran’s Hospital, GRECC, Bedford, Massachusetts, Boston University School of Medicine, Department of Neurology, Cognitive Neuroscience Division of the Alzheimer’s Disease Center

Research has shown that sensory gating is largely modualted by acetylcholine. Diminished levels of acetylcholine and sensory gating deficits have been reported in research involving Alzheimer’s disease (AD) patients. However, there has been little investigation into those with a family history (FH+) of AD. The rationale of this study was to determine whether sensory gating impairments could distinguish those with early AD from individuals with increased risk for the disease while replicating previous findings of gating abnormalities in AD patients. Using the paried-click paradigm, evoked potentials were recorded from 4 groups of 20 subjects per group (AD, older controls, FH+, FH-). The results showed that while the AD group demonstrated sensory gating abnormalities, the FH+ group did not when compared to their peers with no family history of the disease (FH-). These results are discussed in relation to previous findings reporting P300 abnormalities in the FH+ group.

Key Words: Alzheimer’s disease • sensory gating • P50 • at risk

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 21, No. 6, 439-447 (2007)
DOI: 10.1177/1533317506292282


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