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American Journal of Alzheimer's Disease and Other Dementias®, Vol. 21, No. 6, 411-415 (2007)
DOI: 10.1177/1533317506294925

Depressive Symptoms Associated With Hereditary Alzheimer’s Disease: A Case Description

Mònica Yicette Sànchez Contreras, MD

Centro de Biologìa Molecular y Biotecnologìa, Universidad Tecnològica de Pereira, Facultad de Ciencias de la Salud, La Julita, Colombia, cenbiotep{at}utp.edu.co, jmurkin{at}uwo.ca

Paula Alejandra Osorio Vargas

Centro de Biologìa Molecular y Biotecnologìa, Universidad Tecnològica de Pereira, Facultad de Ciencias de la Salud, La Julita, Colombia

Lucero Rengifo Ramos, MSc

Centro de Biologìa Molecular y Biotecnologìa, Universidad Tecnològica de Pereira, Facultad de Ciencias de la Salud, La Julita, Colombia

Rafael Alarcòn Velandia, MSc

Grupo de Psicogeriatrìa "Clinica de la Memoria, las Demencias y el Envejecimiento," Programa Clìnica de la Memoria, Colombia

The authors describe a family group studied by the Centro de Biologìa Molecular y Biotecnologìa, and the Clìnica de la Memoria, las Demencias y el Envejecimiento (Universidad Tecnològica de Pereira, Colombia), and evaluate the association of depressive symptoms with Alzheimer’s disease (AD). This family presented a hereditary pattern for AD characterized by an early onset of dementia symptoms, a long preclinical depressive course, and, once the first symptoms of dementia appeared, a rapid progression to severe cognitive function impairment. The authors found a high prevalence of depressive symptoms in this family and propose that the symptoms could be an important risk factor for developing AD in the presence of other risk factors such as the APOE E4 allele.

Key Words: depression • Alzheimer’s disease • APOE


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