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American Journal of Alzheimer's Disease and Other Dementias®
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Systemic Inflammatory Markers and Risk of Dementia

Tomasz Dziedzic, MD, PhD

Department of Neurology, Jagiellonian University, Botaniczna 3, 31-503 Krakow, Poland; dziedzic{at}cm-uj.krakow.pl

Inflammation plays an important role in the pathogenesis of Alzheimer's disease. This article reviews the results of prospective studies demonstrating that the level of systemic inflammation markers, particularly C-reactive protein and interleukin-6, can predict cognitive decline or dementia. The potential mechanisms linking systemic inflammatory molecules to cognitive decline are also discussed.

Key Words: Alzheimer's disease • dementia • inflammation

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 21, No. 4, 258-262 (2006)
DOI: 10.1177/1533317506289260
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