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American Journal of Alzheimer's Disease and Other Dementias®, Vol. 21, No. 3, 175-181 (2006)
DOI: 10.1177/1533317506289256

Laminar Distribution of ß-Amyloid Deposits in Dementia With Lewy Bodies and in Alzheimer’s Disease

Richard A. Armstrong, DPhil

Vision Sciences, Aston University, Birmingham, United Kingdom, r.a.armstrong{at}aston.ac.uk

This study tested whether the laminar distribution of the ß-amyloid (Aß) deposits in dementia with Lewy bodies (DLB) cases with significant Alzheimer’s disease (AD) pathology (DLB/AD) was similar to "pure" AD. In DLB/AD, the maximum density of the diffuse and primitive deposits occurred either in the upper laminae or a bimodal distribution was present with density peaks in the upper and lower laminae. A bimodal distribution of the classic Aß deposits was also observed. Compared with AD, DLB/AD cases had fewer primitive deposits relative to the diffuse and classic deposits; the primitive deposits exhibited a bimodal distribution more frequently, and the diffuse deposits occurred more often in the upper laminae. These results suggest that Aß pathology in DLB/AD may not simply represent the presence of associated AD.

Key Words: dementia with Lewy bodies (DLB) • Alzheimer’s disease (AD) • ß-amyloid (Aß) deposits • laminar distribution • cortico-cortical pathways


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