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American Journal of Alzheimer's Disease and Other Dementias®
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Family history of dementia does not influence the progression of Alzheimer's disease at two years: Results from the REAL.FR Study

Frédéric Cortes, DEA

Sophie Gillette-Guyonnet, PhD

Fati Nourhashemi, MD, PhD

Cantet Christelle

Bruno Vellas, MD, PhD

Service de Medecine Interne et Gerontologie Clinique, Toulouse, France

The purpose of this study was to determine whether a family history of dementia in afirst-degree relative influenced the progression of Alzheimer s disease (AD) after two years offollow-up. Patients were recruited in the REAL.FR (Reseau sur la Maladie d'Alzheimer Franqais) study and underwent behavioral, global, nutritional, and medical evaluation with assessment ofcognitivefunction and independence every six months. At inclusion, 113 patients reported a family history of dementia, and 358 patients had no family history of dementia. There was no statistical difference for any factors between the two groups at baseline. After two years offollow-up, a similar percentage of patients were still followed in each group, and although most parameters showed significant deterioration, there was no difference between the two groups, indicating that a family history of dementia does not appear to influence the progression of AD.

Key Words: Alzheimer's disease • family history of dementia • progression

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 21, No. 2, 131-136 (2006)
DOI: 10.1177/153331750602100214
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L. A Morrow, B. E Snitz, E. G Rodriquez, K. A Huber, and J. A Saxton
High medical co-morbidity and family history of dementia is associated with lower cognitive function in older patients
Fam. Pract., October 1, 2009; 26(5): 339 - 343.
[Abstract] [Full Text] [PDF]


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