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American Journal of Alzheimer's Disease and Other Dementias®
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Recognition and treatment of Alzheimer's disease: A case-based review

Dana M. Marseille, MD

Daniel H.S. Silverman, MD, PhD

Neuronuclear Imaging Section, Division of Biological Imaging, David Geffen School of Medicine, University of California at Los Angeles Medical Center, Los Angeles, California

Early recognition and treatment initiation are pivotal in managing Alzheimer k disease (AD). Once a diagnosis of AD is made, a treatment plan is developed and should include treatment initiation with cholinesterase inhibitors (ChEfs) to improve cognition, management of comorbid conditions, and treat behavioral symptoms. Caregiver compliance is integral to AD treatment success. The purpose of this report is to present two real case studies of "suspected" AD or related dementia and stress the significance of early and accurate diagnosis in disease management. In case 1, a caregiver reports gradual but progressive loss of memory, and the patient himself complains of memory impairment. Neuroimaging analysis confirms "typical" AD. In case 2, initiation of ChEI therapy is followed by substantial clinical improvement in the face of a complex medical picture, and neuroimaging revealing more neurodegenerative changes than could be accountedfor by "pure" AD.

Key Words: Alzheimer's disease • cholinesterase inhibitor • dementia • caregiver • case study

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 21, No. 2, 119-125 (2006)
DOI: 10.1177/153331750602100212
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