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Computerized cognitive testing battery identifies mild cognitive impairment and mild dementia even in the presence of depressive symptoms

Department of Clinical Science, NeuroTrax Corporation, New York, New York

Tzvi Dwolatzky, MD

Memory Disorders Clinic and Department of Geriatrics, Shaare Zedek Medical Center and The Ramat Tamir Home for the Aged, Jerusalem, Israel

David M. Zucker, PhD

Department of Statistics, Hebrew University, Jerusalem, Israel

Howard Chertkow, MD

Department of Clinical Neurosciences, McGill University, Montreal, Quebec, Canada

Howard Crystal, MD

Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York

Avraham Schweiger, PhD

Department of Behavioral Sciences, Academic College of Tel Aviv, Tel Aviv, Israel

Ely S. Simon, MD

Department of Clinical Science, NeuroTrax Corporation, New York, New York

Cognitive and depressive symptoms co-occur, complicating detection of mild cognitive impairment (MCI) and early dementia. In this study, discriminant validity of a novel computerized cognitive battery for MCI detection was evaluated after covariation for depressive symptom severity. In addition to the computerized battery, participants at two sites received the 30-item self-administered Geriatric Depression Scale (GDS; n = 72); those at two other centers received the observer-administered Cornell Scale for Depression in Dementia (CSDD; n = 88). In both cohorts, a Global Cognitive Score and memory, executive function, visual spatial, and verbal index scores discriminated among cognitively healthy, MCI, and mild dementia groups after covariation for GDS or CSDD, respectively (p < 0.05). Thus, the computerized battery for detection of mild impairment is robust to comorbid depressive symptoms, supporting its clinical utility in identifying neurodegenerative disease even in elderly with depression.

Key Words: mild cognitive impairment • depression • dementia • cognitive assessment • computerized battery

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 21, No. 1, 28-36 (2006)
DOI: 10.1177/153331750602100105


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