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American Journal of Alzheimer's Disease and Other Dementias®
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{alpha}-Synuclein aggregation in pathological aging and Alzheimer's disease: The impact of ß-amyloid plaque level

Sara M. Lippa

Carol F. Lippa, MD

Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

Hiroshi Mori, PhD

Osaka City University Medical School, Osaka, Japan.

In central nervous system diseases, abnormal aggregation of one protein is often associated with aggregation of other proteins. To begin to assess whether ß-amyloid (Aß) is associated with {alpha}-synuclein (AS) aggregation [secondary Lewy body (LB) formation], we used immunohistochemical techniques to compare the amygdala of 11 subjects with pathological aging and 18 with Alzheimer's disease. Overall, Aß-40 plaque level was greater in cases with secondary AS aggregates. Aß42 plaque level was not associated with AS aggregation. Aß-40 plaque levels cannot be ruled out as a factor involved in secondary LB formation.

Key Words: Alzheimer's disease • ß-amyloid • {alpha}-synuclein • Lewy body • pathological aging

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 20, No. 5, 315-318 (2005)
DOI: 10.1177/153331750502000506
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