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American Journal of Alzheimer's Disease and Other Dementias®
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Alleviation of multiple abnormalities by galantamine treatment in two patients with dementia with Lewy bodies

Alvin C. Holm, MD, FACP

Geriatric Behavioral Services, Bethesda Rehabilitation Hospital, St. Paul, Minnesota; University of Minnesota School of Medicine, Minneapolis, Minnesota

Two patients diagnosed with dementia with Lewy bodies (DLB) presented with prominent behavioral disturbances. The first patient experienced well-formed visual hallucinations, movement disorders, and cognitive decline and was increasingly resistant to care. He was treated with galantamine 4 mg bid, which was increased to 8 mg bid after four weeks. Improvements in behavior, attention, and cognition made it possible for this patient to be transferred back to long-term care after 32 days. The second patient had increasing confusion, fluctuating cognition, agitation, and psychosis. He was given donepezil initially, then switched to galantamine 4 mg bid. He was assessed as stable for discharge with improved behavior control after three weeks. Both patients also were receiving an atypical antipsychotic (quetiapine) and an antidepressant (venlafaxine and sertraline, respectively).

Key Words: dementia • Lewy bodies • galantamine • behavioral • antidepressant

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 19, No. 4, 215-218 (2004)
DOI: 10.1177/153331750401900411
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