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Use of a false recognition paradigm in an Alzheimer's disease clinical trial: A pilot study

Harvard Medical School, Boston, Massachusetts; Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Boston, Massachusetts

Kalina J. Michalska, BS

Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Boston, Massachusetts

Dorene M. Rentz, PsyD

Harvard Medical School, Boston, Massachusetts; Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Boston, Massachusetts

Claire C. Joubert, PAC

Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts

Kirk R. Daffner, MD

Harvard Medical School, Boston, Massachusetts; Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Boston, Massachusetts

Daniel L. Schacter, PhD

Department of Psychology, Harvard University, Cambridge, Massachusetts

Reisa A. Sperling, MD

Harvard Medical School, Boston, Massachusetts; Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Boston, Massachusetts

We report the first use of a false recognition memory test in a clinical trial of patients with Alzheimer's disease (AD). Tests of false recognition allow measurement of two components of memory: the specific details of a prior encounter with a particular item (item-specific recollection) and the general meaning, idea, or gist conveyed by a collection of items (gist memory). We used a false recognition paradigm with categorized pictures to study the effects of an experimental medication in patients with AD. Because medications to treat AD may preferentially improve gist memory or item-specific recollection, use of this type of paradigm may improve sensitivity for detection of drug effects more than standard memory tests.

Key Words: Alzheimer's disease • memory • Neotrofin

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 17, No. 2, 93-100 (2002)
DOI: 10.1177/153331750201700204


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