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Interaction between apolipoprotein-E and angiotensin-converting enzyme genotype in Alzheimer's disease

University of Istanbul, Institute for Experimental Medical Research Department of Molecular Medicine, Istanbul, Turkey

Bedia Agaçhan, PhD

Hülya Yilmaz, PhD

Makbule Aydin, PhD

Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey

Ihsan Kara, MD

Institute of Experimental Medical Research, Department of Neurological Science, University of Istanbul, Istanbul, Turkey

Deniz Eker, MD

Engin Eker, MD

Department of Neurogeriatrics, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

Both apolipoprotein-E (apo-E) 4 allele and angiotensinconverting enzyme (ACE) deletion (D) polymorphism have been associated with a high risk for coronary heart disease. Increased frequency of the 4 allele has also been reported in patients with late-onset of familial and sporadic Alzheimer's disease (AD). The primary aim of this study is to examine the possible relationship between the ACE gene polymorphism and AD. The second aim of this study is to explore the relation of the ACE and apo-E genotypes with AD. Polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP), and agarose gel electrophoresis techniques were used to determine the apo-E and ACE genotypes.

The frequencies of ACE D and ACE insertion (I) allele among AD patients and controls were 55.7 percent versus 44.2 percent and 51.7 versus 48.2 percent, respectively. Apo-E allele frequencies in the AD group for 2, 3 and 4 were, 1.7 percent, 96.5 percent, and 1.7 percent, respectively. The apo-E allele frequencies of healthy groups for 2, 3 and 4 were 1 percent, 56 percent, and 1.7 percent, respectively.

In conclusion ACE D and apo 4 allele were found to be more frequent in patients with Alzheimer's disease than in the control group.

Key Words: Alzheimer's disease (AD) • angiotensinconverting enzyme (ACE) • apolipoprotein-E (apo-E) • polymerase chain reaction (PCR) • restriction fragment • length polymorphism (RFLP)

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 16, No. 4, 205-210 (2001)
DOI: 10.1177/153331750101600407


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