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Apolopoprotein-E gene polymorphism and lipid profiles in Alzheimer's disease

Bedia Agaçhan, Phd

Hülya Yilmaz, PhD

Makbule Aydin, MD

Ihsan Kara, MD

Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey

Engin Eker, MD

Deniz Eker, MD

Department of Neurogeriatrics, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

In this study, the relationship between lipid profiles of sera and apolipoprotein E (apo E) gene polymorphism was investigated in 35 patients with Alzheimer's disease (AD) and 29 healthy people.

Apo E genotypes and allele frequencies of the AD patient group were: apo E2/3, 2 (5.7 percent); apo E2/4, 1 (2.9 percent); apo E3/3, 26 (74.3 percent); apo E3/4, 5 (14.3 percent); apo E4/4, 1 (2.9 percent); 2, 3(4.2 percent); 3, 59 (84.2 percent); 4, 8 (11.4 percent). The healthy group's apo E genotypes and allele frequencies were: apo E2/3, 1 (3.4 percent); apo E3/3, 27 (93.1 percent); apo E3/4, 1 (3.4 percent); 2, 1 (1.7 percent); 3, 56 (96.5 percent); 4, 1 (1.7 percent). In Alzheimer's cases, 4 allele frequencies increased significantly as compared to the healthy group (p < 0.05). When the effects of the apo E isoforms on lipid profiles were evaluated, a relationship between apo E 4 allele and high total levels of serum cholesterol was found, whereas of apo E 2 allele was associated with the low total cholesterol of serum, although the difference was not statistically significant (p > 0.05).

This study confirms the association of apo E 4 allele with lipid profiles in AD patients.

Key Words: allele • Alzheimer's disease(AD) • apolipoprotein E (apo E) • genetics • lipid profiles • plaques • polymorphism • tangles

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 16, No. 2, 77-81 (2001)
DOI: 10.1177/153331750101600207


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