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Progranulin and B-Amyloid Distribution: A Case Report of the Brain From Preclinical PS-1 Mutation Carrier
* To whom correspondence should be addressed. E-mail: ggliebus{at}hotmail.com.
 -amyloid (A) plaques. Objective: To investigate PGRN and aggregated A immunolabeling distribution in autopsied brain tissue from the participant with confirmed PS-1 (A246E) mutation, who died prior to clinical symptom onset. Results: Immunolabeling for PGRN was positive and accumulated/formed plaque-like structures in all studied regions. These structures most frequently colocalized with A though there were some that did not. PGRN plaques were most dense in medial temporal and frontal regions and predominated over aggregated A. Conclusions: This case report illustrates PGRN accumulation and A aggregation in preclinical PS-1 AD case and raises the question whether this phenomenon coincides with or precedes A aggregation.
First published on September 23, 2009, doi:10.1177/1533317509346209 |
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