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Cautiousness in testing for Alzheimer's disease

Department of Neurology, Orebro Medical Center Hospital, Orebro, Sweden

Claes Lundberg, MD

Claes Lundberg, MD, Department of Ophthalmology Orebro Medical Center Hospital, Orebro, Nweden

Recently it was suggested that the instilling of tropicamide (an acetylcholine receptor antagonist) in the eye could be a simple diagnostic tool for Alzheimer's disease. The sensitivity was 95 percent and the specificity was 94 percent. However there might be several biological reasons, other than dementia, for a positive eye test and the predictive value of a positive test might be low even if the specificity and sensitivity should prove to be as high as in the presented pilot study.

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 10, No. 4, 37-38 (1995)
DOI: 10.1177/153331759501000409


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