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American Journal of Alzheimer's Disease and Other Dementias®
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Understanding the memory loss of Alzheimer's disease

The most common presenting symptom

Bradley T. Hyman

Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa

Gary W. Van Hoesen

University of Iowa College of Medicine, Iowa City, Iowa

Leslie J. Kromer

Department of Anatomy, University of Iowa College of Medicine, Iowa City, Iowa

Antonio R. Damasio

Division of Behavioral Neurology, University of Iowa College of Medicine, Iowa City, Iowa

Post-mortem examination of the brains of patients with Alzheimer's disease revealed both a regional and a cellular specific pattern of neurofibrillary tangles. The neurons that are affected are crucial projection neurons for memory-related structures in the medial temporal lobes. There loss is likely to interfere with normal learning and memory.

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 1, No. 2, 15-19 (1986)
DOI: 10.1177/153331758600100206
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