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Issues in the clinical diagnosis of Alzheimer's disease

Lemuel Shattuck Hospital and Tufts University School of Medicine, Boston; Center for Memory Impairment and Neurobehavioral Disorders, Brookline, Massachusetts

A review of the issues surrounding the diagnosis of Alzheimer's disease (AD) is presented in this paper. Discussed are complications in diagnosis resulting from inconsistent agreement about what's considered "normal" impairment in the elderly. Also discussed are diagnostic complications resulting from factors other than dementia that produce AD-like symptoms and deficits (depression, psychosocial issues). A definition of AD is presented, along with an explanation of the course of data and is a rived at through the exclusion of other possibilities. Clinical indicators of whether a patient possibly has AD, probably has it, or definitely has it, are also discussed.

American Journal of Alzheimer's Disease and Other Dementias®, Vol. 1, No. 1, 9-15 (1986)
DOI: 10.1177/153331758600100104


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